解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Heart damage induced by chlorpromazine (CPZ) toxicity is associated with changes in the expression of various enzymes and proteins. This study aimed to investigate CPZ‑induced alterations in cardiac E-cadherin and caveolin-1 (cav-1) after CPZ administration. Male Wistar rats were randomly divided into two groups: a co...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.729
更新日期:2012-03-01 00:00:00
abstract::An effective therapeutic strategy for suppressing liver fibrosis should improve the overall prognosis of patients with chronic liver diseases. Although enormous efforts are ongoing to develop anti-fibrotic agents, no drugs have yet been approved as anti-fibrotic agents for humans. Insulin resistance (IR) is reportedly...
journal_title:Molecular medicine reports
pub_type: 杂志文章,随机对照试验
doi:10.3892/mmr.2011.676
更新日期:2012-02-01 00:00:00
abstract::Ribavirin (RBV)-induced anemia is a serious side effect of pegylated interferon (PEG-IFN) plus RBV therapy which is the standard care most effective for hepatitis C virus (HCV) infection. In the present study, we investigated the association of inosine triphosphate pyrophosphatase (ITPA) genotypes with RBV-induced hem...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.659
更新日期:2012-02-01 00:00:00
abstract::Diabetic infected foot is the outcome of progressive vascular and neurological damage caused by persistent chronic hyperglycemia. Due to acute hypoxia and infection, the tissues develop extensive necrosis and gangrene, which often require amputation. The decision regarding the level of amputation relies mainly on the ...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.667
更新日期:2012-02-01 00:00:00
abstract::The present study aimed to evaluate the protein expression of the transmembrane translocase FAT/CD36 and cytoplasmic H-FABP and L-FABP in human trophoblast tissue and evaluate the effects of exogenous leptin upon differential expression of each biomolecule; consequently, it aimed to derive information regarding the ef...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.686
更新日期:2012-02-01 00:00:00
abstract::To determine the effect of the down-regulation of osteopontin (OPN) expression on the sensitivity of breast cancer cells to doxorubicin, a chemotherapeutic drug, OPN shRNA was used to transfect the OPN-positive breast cancer cell line MDA-MB-231. The expression of OPN mRNA and protein was analyzed by RT-PCR and Wester...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.679
更新日期:2012-02-01 00:00:00
abstract::Kallikrein-related peptidase 14 (KLK14) is a member of the tissue kallikrein family of proteases, which are associated with the pathogenesis of malignant tumors and are over-expressed in ovarian carcinoma. However, the mechanism through which KLK14 is implicated in ovarian cancer remains unclear. The aim of the presen...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.625
更新日期:2012-01-01 00:00:00
abstract::We extracted cucurmosin (CUS) from the sarcocarp of Cucrubita moschata (pumpkin). Recently, a number of studies have indicated that CUS has cytotoxic properties and induces apoptosis in a number of human tumor cells. However, the detailed mechanisms are largely unknown. The aim of this study was to confirm CUS's antic...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.605
更新日期:2012-01-01 00:00:00
abstract::Recently, it has been reported that kidney stones are a significant and independent risk factor for chronic kidney disease (CKD) in the general population. However, the prevalence of CKD in patients following successful extracorporeal shockwave lithotripsy (ESWL) has yet to be eluci...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.586
更新日期:2012-01-01 00:00:00
abstract::The aim of this study was to explore the effect of bisphenol A (BPA) on the EGFR-STAT3 pathway in breast cancer. We applied 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay to the analysis of the responsiveness of MCF-7 cells to BPA. Gene expression was assayed at the transcription...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.583
更新日期:2012-01-01 00:00:00
abstract::It is well known that the mammalian associate of Myc-1 (AMY-1) plays a significant role in spermatogenesis or cellular differentiation. A full-length complementary DNA (cDNA) encoding AMY-1 of Schistosoma japonicum (SjAMY-1) was identified and isolated from a cDNA library. The gene contained an open reading frame of 3...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.565
更新日期:2011-11-01 00:00:00
abstract::Chronic bacterial prostatitis (CBP) is a persistent infection of the prostate characterized by poor quality of life mainly due to frequent relapse episodes caused by incomplete eradication of causative pathogens. Aggressive antibacterial therapy is required to attenuate the severe symptoms of CBP and to achieve a perm...
journal_title:Molecular medicine reports
pub_type: 杂志文章,评审
doi:10.3892/mmr.2011.575
更新日期:2011-11-01 00:00:00
abstract::To investigate the association between apolipo-protein E (APOE) polymorphisms and insulin resistance and Traditional Chinese Medicine (TCM) syndromes in type 2 diabetes mellitus (T2DM) with macroangiopathy, 60 patients with T2DM macroangiopathy were enrolled and divided into three groups: dryness-heat due to deficienc...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.546
更新日期:2011-11-01 00:00:00
abstract::Quercetin (a natural polyphenolic compound) is a polyphenolic flavonoid compound found in a variety of plants. It has been demonstrated to exert cytostatic activity against a variety of human cancer cell lines, including the human osteosarcoma cell line, MG-63. However, its effects on osteosarcoma cell apoptosis are s...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.533
更新日期:2011-09-01 00:00:00
abstract::The present study aimed to investigate the expression of the Hedgehog (Hh) signaling pathway between microsatellite-unstable (MSI) and microsatellite-unstable (MSS) colorectal cancers (CRCs). A total of 61 samples of CRC tissue and corresponding blood samples were obtained from the surgical department of our hospital....
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.529
更新日期:2011-09-01 00:00:00
abstract::We investigated the effects of mechanical strain on the progressive ankylosis (ANK) gene and extracellular nucleotide phosphatase/phosphodiesterase (ENPP)1 mRNA expression and TGF-β1 protein expression in rat endplate chondrocytes in vitro. Endplate chondrocytes were isolated and cultured in vitro. Following identific...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.508
更新日期:2011-09-01 00:00:00
abstract::Keratinocytes play an important role in the inflammatory response of the skin. UVB stimulates keratinocytes to secrete several cytokines. To our knowledge, there are no reports that have examined which layer or cell type is responsible for producing these cytokines. Thus, in this study we performed immunohistochemical...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.478
更新日期:2011-07-01 00:00:00
abstract::FW523-3, a new lipopeptide compound, was recently isolated and purified from the culture broth of a marine Micromonospora chalcea. FW523-3 was shown to inhibit the proliferation of certain cancer cells. However, the spectra and the underlying mechanism of its antitumor activity are unclear. In this study, the MTT and ...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.496
更新日期:2011-07-01 00:00:00
abstract::The extracellular signal-regulated kinase (ERK) signaling transduction pathway has been implicated in multiple physiological processes. It is not clear whether the ERK1/2 pathway participates in post-traumatic stress disorder (PTSD). The aim of this study was to provide novel insights into the mechanisms of how the am...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.459
更新日期:2011-05-01 00:00:00
abstract::Dyslipidemia is an important risk factor for myocardial infarction (MI). We previously showed that gene polymorphisms associated with MI differed among individuals with different lipid profiles. We also showed that rs6929846 of BTN2A1 and rs2569512 of ILF3 were significantly associated with MI in Japanese individuals....
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.441
更新日期:2011-05-01 00:00:00
abstract::Semaphorin 6B is a member of the semaphorin family of signaling proteins, which is implicated in a variety of biological processes, such as axon guidance and muscle regeneration. PPARα is known to be a regulator of semaphorin 6B in human cancer cell lines. In this study, we examined the effect of fenofibrate as a PPAR...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.463
更新日期:2011-05-01 00:00:00
abstract::Telomeres are DNA repeats at the ends of linear chromosomes in eukaryotic cells; they form cap-like specialized structures at chromosome ends to protect them from digestion and degradation. With each cell division, somatic cell telomeres progressively wear and shorten, leading to cell senescence. Various environmental...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.436
更新日期:2011-03-01 00:00:00
abstract::Signal transducer and activator of transcription 3 (STAT3) plays an important role in tumor cell survival and proliferation and thus has become a major focus in the development of anti-cancer therapies. Patrinia scabiosaefolia has been used for the treatment of various types of cancer. However, the precise mechanism o...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.413
更新日期:2011-03-01 00:00:00
abstract::The healing of diabetic wounds represents a formidable clinical challenge, and the molecular mechanisms involved in diabetic wound healing are far from clear. In this study, we investigated the expression of β-catenin and cyclin D1 in the epidermal stem cells (ESCs) of diabetic rats, and explored whether the reduction...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2011.435
更新日期:2011-03-01 00:00:00
abstract::G-protein-coupled receptor 30 (GPR30) has been reported to act as a membrane-bound estrogen receptor that is involved in the mediation of non-genomic estradiol signalling. In this study, we demonstrated that male, but not female, GPR30-deficient mice suffer from impaired left‑ventricular cardiac function. Left ventric...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2010.402
更新日期:2011-01-01 00:00:00
abstract::The non-steroidal anti-inflammatory drug-activated gene (NAG-1) is a newly identified member of the transforming growth factor (TGF)-β superfamily and plays significant roles in regulating proliferation and pro-apoptotic activities. In the present study, we studied the regulation of NAG-1 by troglitazone in the cultur...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2010.381
更新日期:2011-01-01 00:00:00
abstract::B7-H1, a recently described B7 family member, has been reported to negatively regulate T-cell function in most cancer cells. In this study, we sought to investigate B7-H1 expression in four uveal melanoma (UM) cells (OCM1, SP6.5, OM431 and VUP) to determine the functional significance of B7-H1 expression in T-cell imm...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2010.397
更新日期:2011-01-01 00:00:00
abstract::Increased CD4+CD25+Foxp3+ regulatory T cells (Tregs) predict poor prognosis in renal cell carcinoma (RCC). The aim of this study was to investigate the underlying causes of the aberrant accumulation of Tregs in RCC. pcDNA3.1-hCOX-2 and control pcDNA3.1 were transfected into the RCC cell line OS-RC-2. Under stimulation...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2010.374
更新日期:2010-11-01 00:00:00
abstract::Irinotecan (CTP-11) is a topoisomerase I inhibitor used in the treatment of colorectal cancer and non-small cell lung cancer (NSCLC). Despite an initial response to therapy, resistance to irinotecan reduces its efficacy. We isolated irinotecan-resistant human NSCLC A549 cells, termed A549/CTP-11R cells. A549/CTP-11R c...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2010.366
更新日期:2010-11-01 00:00:00
abstract::To investigate the genotype-phenotype correlation in Chinese familial and sporadic hypertrophic cardiomyopathy, specific exons of the myosin binding protein-c gene (MYBPC3) were screened in six families with hypertrophic cardiomyopathy (HCM; FHCM) and in 20 patients with sporadic HCM (SHCM) from the Anhui Province reg...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2010.333
更新日期:2010-09-01 00:00:00
abstract::Kashin-Beck disease (KBD) is a degenerative osteoarticular disease of unknown etiology. The management of KBD would benefit from the identification of the biomarkers related to this disease. In this study, mass spectrometry (MS)-based proteomic profiling was used to identify potential biomarkers of the disease. One hu...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2010.327
更新日期:2010-09-01 00:00:00
abstract::Promoter hypermethylation is a marginal approach to inactivating tumor suppressor genes in cancer. DNA hypermethylation is a well-recognized epigenetic malfunction observed in several malignancies, most predominantly in prostate cancer. Aberrant DNA methylation patterns are considered to be the earliest somatic genome...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr.2010.348
更新日期:2010-09-01 00:00:00
abstract::The dysregulation of renin-angiotensin system-signaling is a contributing factor to the development of atherosclerosis and cardiovascular disease. We studied the progression of angiotensin II (AngII)-induced arterial wall atherosclerosis after its induction. Atherosclerosis was accelerated in ApoE (-/-) C57B6 mice by ...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr_00000298
更新日期:2010-07-01 00:00:00
abstract::Excessive accumulation of β-amyloid (Aβ) has been proposed as a pivotal event in the pathogenesis of Alzheimer's disease. Possible mechanisms underlying Aβ-induced neuronal cytotoxicity include oxidative stress and apoptosis. Reactive oxygen species (ROS) have been proposed to be involved in the apoptotic mechanism of...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr_00000308
更新日期:2010-07-01 00:00:00
abstract::Retroviral vectors have been considered the most promising vehicles for the transfer of therapeutic genes into cells of the hematopoietic system. In clinical studies, however, cases of leukemoid clonogenic expansion of the transduced cells in vivo caused by semirandom integration of the foreign DNA in the genome have ...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr_00000318
更新日期:2010-07-01 00:00:00
abstract::Nutrients are known to display pharmacologic activity against viruses and to exert cooperative effects in cells. To study the influence of nutrient cooperation on HIV production in chronically infected T lymphocytes, we evaluated the individual and combined effects of nutrients on HIV-1 reverse transcriptase (RT) rele...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr_00000268
更新日期:2010-05-01 00:00:00
abstract::Lipids extracted from Halocynthia roretzi contain n-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid, as well as carotenoids. The aim of the present study was to evaluate the effect of H. roretzi lipids on white adipose tissue (WAT) weight and high blood glucose levels in diabetic/o...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr_00000278
更新日期:2010-05-01 00:00:00
abstract::Numerous studies have shown that N-nitrosamines and their precursors are probable etiological factors for esophageal cancer. Certain N-nitrosamines have been shown to induce esophageal cancer in animal models. However, the molecular mechanisms by which N-nitrosamines promote esophageal carcinogenesis remain poorly und...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr_00000288
更新日期:2010-05-01 00:00:00
abstract::Extraocular dissemination is the main cause of death in patients with retinoblastoma (RB) in developing countries, and there are few molecular markers that are useful for the evaluation of minimal disseminated disease. The GD2 ganglioside is known to be expressed by RB cells that metastasize in bone marrow, and the ac...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr_00000248
更新日期:2010-03-01 00:00:00
abstract::In the present study, optically active cis and trans α-hydroxy-β-lactams were prepared by Baker's yeast reduction of a racemic α-keto-β-lactam and by the hydrolysis of a racemic α-acetoxy β-lactam with the resting cells of Bacillus Subtilis. ...
journal_title:Molecular medicine reports
pub_type: 杂志文章
doi:10.3892/mmr_00000258
更新日期:2010-03-01 00:00:00